The researchers report based on a series of pre clinical studies that tamoxifen increases binding of ER beta to mutated TP53 in TNBC leading to death of cancer cells, and their analysis of a large breast cancer patient database showed that high levels of ER beta in TNBC with mutated TP53 are associated with a more favorable prognosis
In accordance, the higher number of bilateral breast reconstructions in the IBR group could be related to a higher number of prophylactic contralateral mastectomies in conjunction with breast reconstruction in this group